Ophthalmic erythromycin is an antibiotic used to  prevent bacterial infections of the eye in newborn babies.

Benefits: Erythromycin ointment in the eyes of a newborn is a standard practice in many hospitals across the nation. It is used to prevent gonococcal ophthalmia neonatorum, which may cause blindness in 0.3% (3 out of a thousand) of infected infants. The most effective manner of preventing ophthalmia neonatorum (ON) is testing mothers for gonorrhea and chlamydia early in pregnancy. Erythromycin prophylaxis may be especially helpful in geographic regions where rates of chlamydia and gonorrhea are very high and prenatal care rates are very low. Erythromycin prophylaxis may be helpful if the mother and her partner(s) did not receive adequate screening and treatment for gonorrhea during the pregnancy and it’s not possible to test the mother at the time of birth and treat the infant as needed . If the mother and her partner are tested and are negative for these diseases and they are in a monogamous relationship, the likelihood that the infant will be affected by the disease is zero.

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Risks: Adverse effects include eye irritation and blurred vision, which may interfere with bonding. Widespread use may contribute to the development of antibiotic resistant bacteria. Erythromycin is not 100% effective at preventing ON (it has a 20% failure rate). Another disadvantage is that a woman may test negative for chlamydia or gonorrhea, but then be infected by a partner before giving birth. Erythromycin ointment can cause chemical conjunctivitis, 

Please refer to evidencedbasedbirth.com for more info